Cardiometabolic outcomes of women exposed to hyperglycaemia first detected in pregnancy at 3-6 years post-partum in an urban South African setting.

Cardiometabolic outcomes of women exposed to hyperglycaemia first detected in pregnancy at 3-6 years post-partum in an urban South African setting.

Blog Article

BackgroundHyperglycaemia first detected during pregnancy(HFDP) has far-reaching maternal consequences beyond the pregnancy.Our study evaluated the cardiometabolic outcomes in women with prior HFDP versus women without HFDP 3-6 years post-partum in urban South Africa.Design and methodsA prospective cohort study was performed of 103 black African women with prior HFDP and 101 without HFDP, 3-6 years post-partum at Chris Hani Baragwanath Academic Hospital, Soweto.Index pregnancy data was obtained from medical records.

Post-partum, participants were re-evaluated for anthropometric measurements, body composition utilizing dual energy X-ray texstar peach absorptiometry(DXA) and biochemical analysis (two-hour 75gm OGTT fasting insulin, lipids, creatinine levels and glucose levels).Cardiovascular risk was assessed by stoneraven d2 Framingham risk score(FRS).Carotid intima media thickness(cIMT) was used as a surrogate marker for subclinical atherosclerosis.Factors associated with progression to cardiometabolic outcomes were assessed using multivariable logistic and linear regression models.

ResultsForty-six(45.1%) HFDP women progressed to diabetes compared to 5(4.9%) in non HFDP group(pConclusionWomen with a history of HFDP have a higher risk of cardiometabolic conditions within 6 years post-partum in an urban sub-Saharan African setting.